A recent study from the University of Rhode Island has found a concerning link between exposure to micro- and nanoplastics and Alzheimer's-like conditions in mice. The research, led by pharmacy assistant professor Jaime Ross, builds upon previous findings showing that these tiny plastic particles can infiltrate the body, including the blood-brain barrier, which protects the brain from harmful substances.
The study focused on mice genetically modified to carry the APOE4 gene, a significant risk factor for Alzheimer's disease. Researchers exposed these mice, along with a control group carrying the APOE3 gene, to micro- and nanoplastics in their drinking water for three weeks. As expected, the plastic particles infiltrated the mice's organs, including their brains.
Cognitive tests revealed that the APOE4 mice, particularly the males, exhibited behavioural changes indicative of cognitive decline after microplastic exposure. They displayed a tendency to wander more in open spaces, a behaviour that would make them more vulnerable to predators. This suggests that microplastic accumulation in the brain can lead to cognitive impairments and increase the risk of Alzheimer's disease, particularly in individuals with genetic predispositions.
The study highlights the potential dangers of widespread microplastic exposure and calls for further research into the cognitive effects of these environmental toxins. Professor Ross encourages continued investigation into this area, hoping to inform better regulation of microplastics and protect public health from their harmful effects.
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